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Skin biopsy demonstrating small fiber pathology. (A) Low‐power image of skin biopsy from patient 3, showing protein gene product 9.5‐immunoreactive fibers (arrow heads) crossing the basement membrane of the epidermis (dashed line). The area framed in yellow is shown enlarged in the next image. (B) High‐power image showing single intraepidermal nerve fiber (red arrow) crossing the basement membrane of the epidermis (blue dashed line). Scale bars represent 100 μm.
