TABLE 1.
Multivariable HRs for the risk of overall death or COVID‐19‐related death in patients with postvaccination COVID‐19 versus unvaccinated COVID‐19
| Variable | Overall death | COVID‐19‐related death | ||
|---|---|---|---|---|
| aHR (95% CI) | p‐Value | aHR (95% CI) | p‐Value | |
| Number of patients | 762 | – | 762 | – |
| Number of events | 87 | – | 64 | – |
| Group | ||||
| Control | REF | REF | ||
| Vaccine | 0.25 (0.12, 0.49) | <0.0001 | 0.27 (0.13, 0.60) | 0.0011 |
| Location, n (%) | ||||
| Northeast | REF | REF | ||
| Southeast | 1.13 (0.51, 2.53) | 0.7606 | 1.42 (0.55, 3.65) | 0.4726 |
| Midwest | 1.30 (0.64, 2.64) | 0.4759 | 1.46 (0.61, 3.48) | 0.3914 |
| South | 0.61 (0.26, 1.42) | 0.2528 | 0.87 (0.32, 2.38) | 0.7897 |
| Northwest | 2.47 (0.98, 6.23) | 0.0557 | 2.53 (0.82, 7.81) | 0.1067 |
| Southwest | 1.54 (0.68, 3.49) | 0.2992 | 2.29 (0.91, 5.80) | 0.0801 |
| Age | 1.05 (1.02, 1.08) | 0.0015 | 1.06 (1.02, 1.10) | 0.0012 |
| BMI | 1.00 (0.97, 1.02) | 0.6657 | 1.01 (0.98, 1.03) | 0.6598 |
| Diabetes | ||||
| No | REF | REF | ||
| Yes | 0.92 (0.56, 1.53) | 0.9894 | 0.78 (0.45, 1.34) | 0.3673 |
| Etiology at cirrhosis | ||||
| NAFLD | REF | REF | ||
| Alcohol | 1.01 (0.49, 2.08) | 0.9894 | 1.41 (0.64, 3.12) | 0.3942 |
| HCV+Alcohol | 0.68 (0.32, 1.43) | 0.3043 | 0.51 (0.20, 1.29) | 0.1544 |
| HCV | 0.85 (0.45, 1.59) | 0.6024 | 0.93 (0.52, 2.17) | 0.8666 |
| Others | 0.29 (0.07, 1.18) | 0.0841 | NA | NA |
| AUDIT‐C score | ||||
| Low | REF | REF | ||
| High | 1.17 (0.53, 2.57) | 0.6902 | 1.21 (0.47, 3.06) | 0.6959 |
| eCTP | ||||
| A | REF | REF | ||
| B | 1.06 (0.60, 1.89) | 0.8335 | 0.83 (0.42, 1.62) | 0.5747 |
| C | 1.28 (0.11, 4.17) | 0.6659 | N/A | N/A |
| Dexamethasone | ||||
| No | REF | REF | ||
| Yes | 4.25 (2.08, 8.69) | < 0.0001 | 3.78 (1.55, 9.22) | 0.0035 |
| Remdesivir | ||||
| No | REF | REF | ||
| Yes | 0.75 (0.33, 1.70) | 0.4926 | 1.41 (0.55, 3.62) | 0.4778 |
| MELD‐Na | 1.03 (0.99, 1.08) | 0.1183 | 1.04 (0.99, 1.09) | 0.1661 |
| PPI exposure | ||||
| No | REF | REF | ||
| Yes | 1.61 (1.06, 2.15) | 0.0007 | 1.08 (0.55, 1.54) | 0.7511 |
| Median household income per $1000 | 0.98 (0.93, 1.07) | 0.1567 | 0.99 (0.97, 1.03) | 0.1078 |
Abbreviations: aHR, adjusted HR; AUDIT‐C, Alcohol Use Disorders Identification Test–Concise; BMI, body mass index; COVID‐19, coronavirus disease 2019; eCTP, electronic Child Turcotte Pugh; MELD‐Na, Model for End‐Stage Liver Disease–Sodium; NA, not available; PPI, proton pump inhibitor.
Bold indicates p < 0.05.