Table 3.

Accuracies of non-invasive tests (NITs) for diagnosis of fibrosis, significant fibrosis, advanced fibrosis, and cirrhosis

NIT	Fibrosis (≥ stage 1)			Significant fibrosis (≥ stage 2)			Advanced fibrosis (≥ stage 3)			Cirrhosis (= stage 4)			Ref
	AUROC	Sensitivity (%)	Specificity (%)	AUROC	Sensitivity (%)	Specificity (%)	AUROC	Sensitivity (%)	Specificity (%)	AUROC	Sensitivity (%)	Specificity (%)
APRI	0.83	79–82	73–83	0.54–0.87	60–69	69–77	070–0.78	33–73	67–91	0.75–0.77	56–62	72–86	[81–84]
FIB-4	0.76	79–83	50–73	0.56–0.85	62–65	70–75	0.77–0.80	32–78	70–96	0.82–0.85	65–76	80–83	[81–83, 85]
VCTE	0.78–0.85	64–82	65–88	0.83–0.86	65–94	58–80	0.85–0.91	70–88	66–90	0.89–0.94	70–100	77–91	[81, 93–96]
pSWE	0.77–0.88	64–79	76–86	0.85–0.86	69–75	83–85	0.89–0.94	80–87	86–87	0.90–0.93	76–87	87–88	[95, 100, 101]
SWE	0.65–0.92	53–83	90–100	0.72–0.91	71–87	67–95	0.72–0.95	72–90	72–92	0.88–0.97	78–100	84–86	[81, 83, 93, 95, 96, 102]
MRE	0.80–0.97	60–83	73–98	0.88–0.97	73.2–94	85–95	0.92–0.98	83–92	83–96	0.90–0.99	81–98	81–94	[81, 83, 93–95, 97–100, 102]
DWI/IVIM	0.83–0.89	72–87	67–91	0.79–0.87	71–82	69–84	0.83–0.89	60–82	77–89	0.86–0.88	80–87	73–77	[99, 103–105]
LSN	0.85–0.90	65–77	88–100	0.80–0.93	68–80	62–97	0.84–0.98	67–89	84–89	0.83–0.96	90–98	79–85	[110–114]

The numbers are from single reference or multiple references when the values are single or in range, respectively

The values may not be applicable to chronic liver diseases not evaluated

AUROC Area under receiver operating curve (0 to 1), APRI aspartate to platelet ratio index, FIB-4 Fibrosis-4, VCTE vibration controlled transient elastography, pSWE point shear wave elastography, 2D SWE two-dimensional shear wave elastography, MRE magnetic resonance elastography, DWI diffusion weighted imaging, IVIM Intravoxel incoherent imaging, LSN liver surface nodularity