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. 2022 Sep 23;13:949535. doi: 10.3389/fendo.2022.949535

Table 1.

List of clinical trials studies on extraction sockets healing in patients with diabetes.

Intervention Year Study design Results Reference
PRGF 2014 Retrospective, split-mouth study PRGF reduced residual socket volumes and improved Healing Indices (99)
L-PRF 2019 Prospective, double-blind, split-mouth study L-PRF enhanced bone density (p=0.007) (100)
2019 Prospective, randomized, double-blind, controlled study L-PRF and HA mucosa improved healing scores within 3 weeks (101)
A-PRF 2019 Randomized, split-mouth, double-blind Study A-PRF slightly affected PD positively (102)
HA 2020 Randomized controlled split-mouth study The sockets healing was better in the HA group, especially on day 10 (p=0.006) and day 15 (p=0.021) (103)
MICD 2016 Prospective study MICD reduced SOD significantly and improved chewing ability within 3 weeks (104)

L-PRF leukocyte- and platelet-rich fibrin, A-PRF advanced platelet-rich fibrin, HA hyaluronic acid, PD pocket depth, MICD maxillary immediate complete denture, SOD socket opening diameters