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. 2022 Sep 23;12:963314. doi: 10.3389/fonc.2022.963314

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Copyright © 2022 Sahashi, Kato, Yoshida, Hayashi, Naitoh, Hori, Natsume, Jinno, Kachi, Asano, Toyohara, Kito, Ammanamanchi and Kataoka

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A proposed model of the mechanism. UA treatment reduces cell proliferation by inhibiting the activation of AKT, and inducing autophagy via the WNK1 pathway. As a result, cancer cell survival is suppressed by UA in cholangiocarcinoma cells.