. 2022 Sep 8;11:1018. [Version 1] doi: 10.12688/f1000research.125432.1

Table 2. MASCO-driven rhythms in circadian gene mutant and engineered mice.

Gene disrupted	Line	Strain	Sex	Age (wks)	Activity recording	MA dosage (%)	Circadian period (h)										References
							DD					LL
							Baseline	Dissociation	MA treated		MA post-treatment	Baseline	Dissociation	MA treated		MA post-treatment
							Baseline	Dissociation	1st component	2nd component	MA post-treatment	Baseline	Dissociation	1st component	2nd component	MA post-treatment
Clock	Δ19 mutant	C57BL/6J	NA	12-16	Wheel	0.0075, 0.012, 0.0225 ^a	AR	No	∼29		AR or 28.5						Coward et al., 2001 ¹¹
Clock	Δ19 mutant	BALB/c	♀	6-19	Wheel	0.005	AR	No	27.5-42.9		26.8-29.3						Masubuchi et al., 2001 ¹²
Clock	Δ19 mutant	C57BL/6	NA	NA	Wheel	0.005	27.83	No	28.5								Mohawk et al., 2009 ¹⁴
Cry1 and Cry2	Global KO	C57BL/6	♀	12	Wheel	0.0025	AR	No	20.8-32.3		AR or 22.3						Honma et al., 2008 ¹³
Cry1 and Cry2	Global KO	C57BL/6	NA	NA	Wheel	0.005	AR	No	24.50-35.33								Mohawk et al., 2009 ¹⁴
Cry1 and Cry2 (SCN-X)	Global KO	C57BL/6	NA	NA	Wheel	0.005	AR	No	26.67								Mohawk et al., 2009 ¹⁴
Bmal1	Global KO	C57BL/6	NA	NA	IR	0.0035 → 0.005	AR	No	32.77								Mohawk et al., 2009 ¹⁴
Bmal1	Global KO	C57BL/6J	NA	NA	Wheel	0.00125 → 0.0025 → 0.005 → 0.01	AR (~4)	No	~6 → ~9 → ~14 → ~20								Blum et al., 2014 ¹⁶
Bmal1	Global KO	C57BL/6J	NA	NA	Wheel	0.01 ^a	AR (~3)	No	∼8								Blum et al., 2014 ¹⁶
Npas2	Global KO	C57BL/6	NA	NA	Wheel	0.005	23.54	No	24.13								Mohawk et al., 2009 ¹⁴
Npas2 (SCN-X)	Global KO	C57BL/6	NA	NA	Wheel	0.005	AR	No	28.17								Mohawk et al., 2009 ¹⁴
Per1 and Per2	Global KO	Mixed	NA	NA	Wheel	0.005	AR	No	27.14								Mohawk et al., 2009 ¹⁴
Per1, Per2, Per3	Global KO	C57BL/6J	♂♀	15	Wheel	0.005	AR	No	21.5								Pendergast et al., 2012 ²²
Per1	Global KO	C57BL/6J	♂♀	6-39	Wheel	0.005	23.49	No	24.71			27.25 (200-300 lux)	No	34.96			Pendergast et al., 2013 ¹⁸
Per1 (SCN-X)							AR	No	29.67			27.25 (200-300 lux)	No	34.96
Per2							23.48	No	23.56			23.40 (200-300 lux)	Yes	23.14	30.03
Per2 (SCN-X)							AR	No	27.75			23.40 (200-300 lux)	Yes	23.14	30.03
Per3							23.51	No	24.26			25.00 (200-300 lux)	No	30.7
Per3 (SCN-X)							AR	No	26.28			25.00 (200-300 lux)	No	30.7
Per1 and Per2							AR	No	23.08 (17.00-32.50)			AR (200-300 lux)	No	17.58, 17.17, 35.33
Per2 and Per3							23.12	No	23.28
Rev Erbα	Global KO with PER2::LUC	C57BL/6J	NA	4-6	IR	0.005	23.36	No	23.25								Salaberry et al., 2017 ²⁸
CK1ε	Tau KI	C57BL/6	NA	NA	wheel	0.005	20.11	Yes	NA	25.86							Mohawk et al., 2009 ¹⁴
CK1ε (SCN-X)	Tau KI	C57BL/6	NA	NA	wheel	0.005	AR	No	34.09								Mohawk et al., 2009 ¹⁴
Human Huntington Disease gene	R6/2 TG	CBAxC57BL/6	♂♀	4.8	IR	0.005 → 0 01	23.7	No	23.7 → 23.1								Cuesta et al., 2012 ²⁹
				4.8		0.005 → 0 01	23.7	Yes	23.7	29.4 → 23.1
				7.5		0.005	∼23.4	No	23.3 → 23.3
Human Huntington Disease gene	R6/2 TG	CBAxC57BL/6	♂♀	6	IR	0.005	∼23.6	No	∼23.6								Ouk et al., 2018 ³⁰
Human Huntington Disease gene	Q175 TG	C57BL/6J	♂♀	9-17	IR	0.005	∼24	Yes	∼24	∼40							Ouk et al., 2016 ³¹
				25-33				No	∼24
				49-56				No	∼24
Gsk3β	Global KO (Heterozygous)	C57BL/6	♂♀	NA	Wheel	0.005	∼23.7	No	∼27.0								Mohawk et al., 2009 ²³

MA: Methamphetamine, DD: Constant darkness, LL: Constant light, AR: arrhythmic, NA: information is not available, IR: Infrared Sensor, SCN-X: SCN-lesioned, →: MA dose increased.

^{^a}

Amphetamine.