Table 2.

Comparison of pan‐CoV fusion inhibitors and SARS‐CoV‐2 nAbs

	Pan‐CoV fusion inhibitors	SARS‐CoV‐2 nAbs
Target	HR1/HR2 in S2 subunit	RBD/NTD in S1 subunit
Conservation of the target	High	Low
Spectrum	Broad	Narrow
Production cost	Low	High
Storage/shipping at	Room temperature	Low temperature
Use in inhalation formulation	Feasible	Difficult
Effectiveness	High	High
Safety	High	High
Half‐life	Short	Long

Abbreviations: HR1, heptad repeat 1; nAbs, neutralizing antibodies; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2.