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. 2022 Aug 21:10.1002/ddr.21982. Online ahead of print. doi: 10.1002/ddr.21982

Table 2.

Inhibition of the activity of the cysteine proteases M,pro papain, PL,pro and hCatL by celastrol

Enzyme IC50 (μM)
Mpro 6.6 ± 0.6
Papain 7.0 ± 0.7
PLpro 8.9 ± 0.8
hCatL 9.6 ± 0.9

Abbreviations: hCatL, human cathepsin L; M,pro promain protease; PL,pro papain‐like protease.