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. 2022 Oct 5;154(11):e202213222. doi: 10.1085/jgp.202213222

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Figure 2. — Ionic and gating current recordings for Shaker and Kv1.2 as well as their mutants at p2 and p7. (A) Family of ionic currents for Shaker-IR. (B) Family of ionic currents for Kv1.2. (C) Family of gating currents for Shaker-IR W434F (p2). (D) Family of ionic currents for Kv1.2 W366F (p2). (E) Family of ionic currents for Shaker-IR W434F/T449V (p2/p7). (F) Family of gating currents for Kv1.2 W366F/V381T (p2/p7). For the ionic current recordings, the holding voltage was −90 mV and step depolarizations were from −80 to +50 mV in 10-mV increments, and the tail voltage was −60 mV. For the gating current recordings, the holding voltage was −120 mV, and step depolarizations were from −110 to +20 mV in 10-mV increments to elicit ON gating currents before stepping back to −120 mV to elicit OFF gating currents. These conditions were applied to all other recordings in this study.