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. 2022 Oct 5;154(11):e202213222. doi: 10.1085/jgp.202213222

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Figure 3. — Ionic and gating currents recordings for mutants at p4 and p7 in the Shaker and Kv1.2 channels. (A) Family of gating currents for Shaker-IR T439V (p4). (B) Family of ionic currents for Kv1.2 S371V (p4). (C) Family of gating currents for Kv1.2 S371V/V381T (p4/p7). (D) Normalized Q–V relations for Kv1.2 W366F/V381T (p2/p7) and Kv1.2 S371V/V381T (p4/p7). Q was obtained by integrating the ON components of the gating current; all data are mean ± SEM; n = 3 for Kv1.2 W366F/V381T (p2/p7) and n = 5 for Kv1.2 S371V/V381T (p4/p7).