Table 2.
The functional effects of Shaker and Kv1.2 mutations
| Shaker | Functional effect | Kv1.2 | Functional effect | |
|---|---|---|---|---|
| WT | W434 | Conducting | W366 | Conducting |
| p2 | W434F | Non-conducting | W366F | Faster inactivation |
| p3 | W435F | Conducting | W367F | Conducting |
| p4 | T439V | Non-conducting | S371V | Faster inactivation |
| p5 | Y445F Y445A |
Faster inactivation Non-conducting |
Y377F Y377A |
Conducting Non-conducting |
| p6 | D447N | Non-conducting | D379N | Non-functional channel |
| p7 | T449V T449A T449K |
Slower inactivation Faster inactivation Faster inactivation |
V381T V381A V381K |
Conducting Faster inactivation Faster inactivation |
| p1/p7 | Q357A/V381T | Conducting | ||
| p2/p7 | W434F/T449 | Faster inactivation | W366F/V381T | Non-conducting |
| p4/p5 | S371T/Y377F | Conducting | ||
| p4/p5/p7 | S371T/Y377F/V381T | Faster inactivation | ||
| p4/p7 | S371V/V381T S371T/V381T |
Non-conducting Conducting |
||
| p5/p7 | Y377F/V381T | Faster inactivation |