TABLE 1.
One hundred and fifty‐one differentially expressed genes and the time points at which they were up‐ or down‐regulated
| B\D | Up | NC | Down | D/C |
|---|---|---|---|---|
| Up | Plb1, Krt19 | Adamts14, Fancd2, Klk1b4 | Up | |
| Fbn1, Ido1, Penk, Klk1b24, Oaf, Col8a2 | Ptgds, Klk1b21, Tmem37, Dgki, Klk1b26, 4833405L11Rik, Cdh22, Sult1a1, Pacs2, Gpc1, Olfml3, Nt5dc2, Prr15l, Atg4a, Gpr39, Lypd1, Arrdc2, Tnnt1, Klk1b16, Lrg1, C530008M17Rik, Slc44a4, Cpne4, Slc7a5, Fkbp5, Mthfd2, Unc5b, Gpr1, 1700028J19Rik, Fam131c, Pik3ip1, Ttyh1, Ccnb1, Usp54, Plekhh1, Ciart, E230001N04Rik, Ankmy1, Glb1l2, Nxph3, Aatk, Cobl, Smoc2, Ankdd1b, Mindy4b‐ps, Frmd4a, Sez6l, Atp7b, Gm38619, Lrrc75b, Sipa1l1, Angptl7, Gm27252, Sec14l4, Platr25, Unc5a, Slc5a3, Cab39l, Mapt, Ptprv, Wdr93, Rabep2, Fstl3, Prss57, Slc27a3, Susd4, 2410002F23Rik, Slc24a4, Mrps6, Frmpd1 | Adamtsl3, Mettl21e, Bmp8a, Slc12a5, Myom1, Gm11716, Klk1b5, Myh11, Dgkk, Asic2, Pkd1l2, Gm38304 | NC | |
| Atp2a1, Map3k6, Cntfr, Otog | Kcnh4, Hif3a, Tpm2, Rnf39, 1600029O15Rik, Chrm2 | Down | ||
| NC | Hmmr, Col4a1, Anln, Col4a2 | Ttyh1, Ccnb1 | Up | |
| Tril, Cpxm2, H6pd, Prelp, F2r, Fbln5, Plat, Nid2, Mlc1 | Tmem145, Srpk1, Zbtb16, Cxcl12, Rptor | NC | ||
| Inhbb | Egr3 | Down | ||
| Down | Ly6g6c, Aplnr, Pbk, Top2a, Adgrl4, Il16, Plbd1, Kdr, Pdgfrb, Sstr2, Rrm2, H2‐Q6, Itgal, Pecam1 | Nmb, Ccnb2, Pomc | Igha | Up |
| Col3a1, Cd74, Nckap1l, H2‐Aa, H2‐DMb1, H2‐Eb1, H2‐Ab1, Mfap4 | Psmb8, Rtn4rl1 | NC |
Note: Genes were clustered into 27 subsets based upon their expression relative to controls in each treatment group vs. group B and group C in rows and group D in columns. Very few genes demonstrate persistent change in expression in the same direction over all three time points.