TABLE 2.
Over‐representation test for classes of genes with significant differential expression in Experiment 3
| PANTHER GO‐Slim Molecular Function | Mus musculus ‐ REFLIST (22265) | Number of genes | Number of expected genes | Over or under represtation | A vs B (fold Enrichment) | (P‐value) | |
|---|---|---|---|---|---|---|---|
| Transporter activity (GO:0005215) | 782 | 10 | 5.41 | + | 1.85 | 0.05 | Atp7b Slc7a5 Ttyh1 Slc24a4 Atp2a1 Slc12a5 Slc27a3 Pkd1l2 Slc5a3 Kcnh4 |
| Ion transmembrane transporter activity (GO:0015075) | 581 | 9 | 4.02 | + | 2.24 | 0.02 | Atp7b Slc7a5 Ttyh1 Slc24a4 Atp2a1 Slc12a5 Pkd1l2 Slc5a3 Kcnh4 |
| Inorganic molecular entity transmembrane transporter activity (GO:0015318) | 550 | 9 | 3.8 | + | 2.37 | 0.01 | Atp7b Slc7a5 Ttyh1 Slc24a4 Atp2a1 Slc12a5 Pkd1l2 Slc5a3 Kcnh4 |
| Kinase activity (GO:0016301) | 572 | 8 | 3.96 | + | 2.02 | 0.05 | Srpk1 Ccnb2 Dgki Dhkk Ccnb1 Pdgfrb Cab39l Map3k6 |
| Phosphotransferase activity, alcohol group as acceptor (GO:0016773) | 534 | 8 | 3.69 | + | 2.17 | 0.03 | Srpk1 Ccnb2 Dgki Dgkk Ccnb1 Pdgfrb Cab39l Map3k6 |
| Metal ion transmembrane transporter activity (GO:0046873) | 310 | 7 | 2.14 | + | 3.26 | 0.01 | Atp7b Slc24a4 Atp2a1 Slc12a5 Pkd1l2 Slc12a5 Kcnh4 |
| Cation transmembrane transporter activity (GO:0008324) | 424 | 7 | 2.93 | + | 2.39 | 0.03 | Atp7b Slc24a4 Atp2a1 Slc12a5 Pkd1l2 Slc5a3 Kcnh4 |
| Inorganic cation transmembrane transporter activity (GO:0022890) | 395 | 7 | 2.73 | + | 2.56 | 0.02 | Atp7b Slc24a4 Atp2a1 Slc12a5 Pkd1l2 Slc5a3 Kcnh4 |
| Active transmembrane transporter activity (GO:0022804) | 218 | 5 | 1.51 | + | 3.32 | 0.02 | Atp7b Slc24a4 Atp2a1 Slc12a5 Slc5a3 |
| Receptor regulator activity (GO:0030545) | 255 | 5 | 1.76 | + | 2.83 | 0.03 | Lypd1 Il16 Inhbb Bmp8a Dkk3 |
| Monovalent inorganic cation transmembrane transporter activity (GO:0015077) | 261 | 5 | 1.81 | + | 2.77 | 0.04 | Slc24a4 Atp2a1 Slc12a5 Slc5a3 Kcnh4 |
| Active ion transmembrane transporter activity (GO:0022853) | 156 | 5 | 1.08 | + | 4.63 | <0.01 | Atp7b Slc24a4 Atp2a1 Slc12a5 Slc5a3 |
| Organic cyclic compound binding (GO:0097159) | 1680 | 4 | 11.62 | − | 0.34 | 0.01 | Chrm Ciart Mrps6 Gata2 |
| Kinase binding (GO:0019900) | 158 | 4 | 1.09 | + | 3.66 | 0.02 | Ccnb2 Nell2 Myom1 Ccnb1 |
| Heterocyclic compound binding (GO:1901363) | 1638 | 4 | 11.33 | − | 0.35 | 0.01 | Chrm2 Ciart Mrps6 Gata2 |
| Calcium ion transmembrane transporter activity (GO:0015085) | 84 | 3 | 0.58 | + | 5.16 | 0.02 | Slc24a4 Atp2a1 Pkd1l2 |
| cytokine activity (GO:0005125) | 116 | 3 | 0.8 | + | 3.74 | 0.05 | Il16 Inhbb Bmp8a |
| Nucleic acid binding (GO:0003676) | 1293 | 3 | 8.94 | − | 0.34 | 0.02 | Ciart Mrps6 Gata2 |
| Carboxypeptidase activity (GO:0004180) | 30 | 2 | 0.21 | + | 9.64 | 0.02 | Cpxm2 Mindy4b‐ps |
| Postsynaptic neurotransmitter receptor activity (GO:0098960) | 49 | 2 | 0.34 | + | 5.9 | 0.05 | Chrm2 Lypd1 |
| Growth factor binding (GO:0019838) | 38 | 2 | 0.26 | + | 7.61 | 0.03 | Gpc1 |
| Glycosaminoglycan binding (GO:0005539) | 42 | 2 | 0.29 | + | 6.88 | 0.03 | Nell2 Rtn4rl1 |
| Acetylcholine receptor activity (GO:0015464) | 28 | 2 | 0.19 | + | 10.33 | 0.02 | Chrm2 Lypd1 |
| Cyclin‐dependent protein serine/threonine kinase regulator activity (GO:0016538) | 35 | 2 | 0.24 | + | 8.26 | 0.02 | Ccnb1 Ccnb2 |
| Acetylcholine binding (GO:0042166) | 28 | 2 | 0.19 | + | 10.33 | 0.02 | Chrm2 Lypd1 |
| Neuropeptide binding (GO:0042923) | 21 | 2 | 0.15 | + | 13.77 | 0.01 | Sstr1 Gpr1 |
| Heparin binding (GO:0008201) | 27 | 2 | 0.19 | + | 10.71 | 0.02 | Nell2 Rtn4rl1 |
| Fibroblast growth factor binding (GO:0017134) | 6 | 1 | 0.04 | + | 24.1 | 0.04 | Gpc1 |
| Lipopolysaccharide binding (GO:0001530) | 7 | 1 | 0.05 | + | 20.65 | 0.05 | Tril |
Note: Genes with differential expression were assessed for over‐enrichment using PANTHER, version 15.0, GO‐slim molecular function. Binomial test with Bonferroni correction was applied to compare the list of differentially expressed genes with that expected.