TABLE 3.

Association between changes in expressed‐miR‐221‐3p and changes in anthropometric, clinical and biochemical variables

Δ	Δ c‐miR‐221
	Crude model			Adjusted model
	β	R 2	p‐value	β	R 2	p‐value
Weight (kg)	0.090	0.110	0.018	0.084	0.106	0.031
Height (cm)	−0.163	0.031	0.215	−0.105	0.021	0.454
BMI (kg/m2)	0.165	0.083	0.041	0.184	0.113	0.026
BMI‐SDS	0.352	0.064	0.074	0.369	0.083	0.062
Fat mass (%)	0.045	0.029	0.236	0.056	0.056	0.142
Waist circumference (cm)	0.052	0.129	0.010	0.050	0.133	0.014
Glucose (mg/dL)	0.009	0.012	0.499	0.004	0.017	0.743
Insulin (μU/mL)	0.019	0.079	0.118	0.016	0.003	0.226
HOMA‐IR	0.073	0.051	0.113	0.060	0.002	0.229
QUICKI	−11.292	0.150	0.028	−11.162	0.095	0.047
Total cholesterol (mg/dL)	0.005	0.041	0.219	0.006	0.102	0.164
HDL‐cholesterol (mg/dL)	0.016	0.036	0.259	0.012	0.045	0.430
LDL‐cholesterol (mg/dL)	0.006	0.030	0.316	0.007	0.073	0.241
Triglycerides (mg/dL)	0.000	0.000	0.998	0.003	0.045	0.421
Leptin (ng/mL)	0.003	0.007	0.719	0.000	0.120	0.952
Total energy (kcal/day)	0.000	0.047	0.137	0.000	0.087	0.061

Abbreviations: BMI, body mass index; BMI‐SDS, standard deviation score for BMI; BP, blood pressure; HOMA‐IR, homeostasis model assessment for insulin resistance; QUICKI, quantitative insulin sensitivity check index.

Bold values are represents p value lower than 0.05.