TABLE 4.

Top pathways regulated by miR‐221‐3p target genes

Rank	Pathway name	p‐value	q‐value (FDR: BH‐method)
1	Pathways in cancer	1.84E‐60	5.91E‐58
2	PI3K‐Akt signalling	2.46E‐41	2.63E‐39
3	Endocytosis	3.41E‐38	2.74E‐36
4	MAPK signalling	5.49E‐38	3.52E‐36
5	Rap1 signalling	8.76E‐33	4.69E‐31
6	cAMP signalling	2.02E‐31	9.29E‐30
7	Regulation of Actin cytoskeleton	6.87E‐31	2.76E‐29
8	Focal adhesion	5.64E‐30	2.01E‐28
9	MiRNAs in cancer	1.05E‐29	3.37E‐28
10	Neuroactive ligand‐receptor interaction	4.96E‐28	1.45E‐26
18	Sphingolipid signalling	1.35E‐21	2.28E‐20
19	mTOR signalling	2.16E‐21	3.47E‐20
20	AMPK signalling	5.93E‐21	9.07E‐20
24	Phospholipase D signalling	1.59E‐19	2.04E‐18
26	Wnt signalling	5.38E‐19	6.40E‐18
27	Insulin signalling	5.77E‐19	6.61E‐18

Note: q‐values: p‐values corrected for multiple testing using the Benjamini–Hochberg method.