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. 2022 Mar 7;14(4):e1788. doi: 10.1002/wnan.1788

TABLE 1.

Overview of studies focusing on the impact of hydrophobicity on the corona formation around different types of nanomaterials

Core material Surface chemistry Protein/media References
Inorganic Core Gold
  • Alkane

  • Ethylene glycol

FBS (Yu et al., 2020)
  • Citrate

  • Glycan

  • PEG

HSA (Meesaragandla et al., 2020)
  • Alkyl ligands

HS (Saha et al., 2016)
  • Methyl

  • Hydroxyl

ApoE, IgE, HSA (Lu et al., 2019)
  • Cetrimonium bromide

  • Poly(styrene sulfonate)

  • Poly(diallyldimethylammonium chloride)

  • Poly(ethylene imine)

  • PEG

HP (Cai et al., 2020)
Silica
  • Pristine

HP (Monopoli et al., 2011)
  • Pristine

  • Amine

  • Carboxyl

HP (Tenzer et al., 2013)
Graphene sheets
  • Pristine

  • Hydroxyl

ApoE, IgE, HSA (Lu et al., 2019)
Mixed core Iron–platinum/poly(maleic anhydride‐alt‐dodecene)
  • PEG

HSA, Fib (Pelaz et al., 2015)
CdSe–ZnS quantum dots/dihydrolipoic acid
  • PEG

  • Zwitterionic

BSA, FBS (Perng et al., 2019)

Magnetite/PLGA

Magnetite/Dextran

Magnetite/phosphatidylcholine

  • Carboxyl

  • PEG

  • Phosphatidylcholine

HP, porcine pulmonary surfactant (Raesch et al., 2015)
Organic Core PLGA
  • Pristine

  • PEG

FBS (Partikel et al., 2019)

HSA

PLGA/Didodecyldimethyl ammonium bromide

  • Pristine

  • PEG

FBS (Gossmann et al., 2015)
Polystyrene
  • Pristine

  • Amine

  • Carboxyl

HP (Tenzer et al., 2013)
  • Pristine

  • PEG

  • PPE

HP (Simon et al., 2018);
  • Pristine

  • PPE

HSA (Müller et al., 2017)
  • Sulfonate

HP (Monopoli et al., 2011)

Polystyrene

Methylstyrene,

Tert‐butylstyrene

Methylmethacrylate

Acrolein

HP (Gessner et al., 2000)
NIPAM/BAM HP, HSA, Fib (Cedervall et al., 2007)

Abbreviations: ApoE, apolipoprotein E; BSA, bovine serum albumin; CdSe‐ZnS, cadmium selenide zinc sulfide; FBS, fetal bovine serum; fib, fibrinogen; HP, human plasma; HS, human serum; HSA, human serum albumin; IgE, immunoglobulin E; NIPAM/BAM, N‐isopropylacrylamide/N‐tert‐butylacrylamide; PEG, poly(ethylene glycol); PLGA, poly(d,l‐lactide‐co‐glycolide); PPE, poly(phosphoester).