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. 2022 Sep 23;13:984376. doi: 10.3389/fimmu.2022.984376

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Copyright © 2022 Shields, Tadros, Al-Hakim, Nell, Lin, Chan, Goddard, Dempster, Dziadzio, Patel, Elkalifa, Huissoon, Duncan, Herwadkar, Khan, Bethune, Elcombe, Thaventhiran, Klenerman, Lowe, Savic, Burns and Richter

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(A) Comparison of the cumulative incidence of individuals in the COV-AD study (n = 534) and the general UK population (n = 54,400,000) testing positive for SARS-CoV-2 at least once between April 2020 and April 2022. Data for the UK population is sourced from the UK Office of National Statistics (14). (B) Comparison of the timing of SARS-CoV-2 infection in Cohort B compared to the general population between January 2021 and April 2022. Between January 2021 and April 2022 there were 19,379,700 PCR+ SARS-CoV-2 infections in the general population (red bars) and 155 PCR+ SARS-CoV-2 infections in cohort B (blue bars). The proportion of the total number of infections occurring between January 2021 and April 2022 are shown monthly for each group (e.g. January 2021, general population: 1,223,983/19,379,700 infections occurred; 6.3% of all infections between January 2021 and April 2022). (C) Comparison of the timing of hospitalization from COVID-19 in Cohort B compared to the general population between January 2021 and April 2022. Between January 2021 and April 2022 there were 571,254 hospitalizations for COVID-19 in the general population (red bars) and 28 hospitalization for COVID-19 in cohort B (blue bars). The proportion of the total number of hospitalization occurring between January 2021 and April 2022 are shown monthly for each group (e.g. January 2021, general population: 113,145/571,254 hospitalization occurred; 19.8% of all hospitalizations between January 2021 and April 2022). (D) Comparison of the time to SARS-CoV-2 viral clearance in serological responders (n = 22) and non-responders (n = 21) to prior infection or vaccination. (E) Comparison of time to SARS-CoV-2 viral clearance in paired nasopharyngeal and sputum samples.