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. 2022 Oct 6;5(10):e2235068. doi: 10.1001/jamanetworkopen.2022.35068

Table 3. Associations Between African Ancestry and Alzheimer Dementia Biomarkers.

Biomarker	Unadjusted		Adjusted^a
Biomarker	Estimate (SE)^b	P value	Estimate (SE)^b	P value
Plasma
Aβ42	0.55 (0.99)	.58	−3.11 (3.77)	.41
Aβ40	−35.40 (13.82)	.01	−96.97 (65.27)	.14
p-tau₁₈₁	−7.26 (3.00)	.02	10.36 (16.15)	.52
Aβ42/Aβ40	0.01 (0.01)	.009	0.02 (0.02)	.40
NFL	−3.97 (1.13)	<.001	−0.26 (5.69)	.96
CSF
AlzBio Innotest
Aβ42	23.63 (14.10)	.10	−12.38 (86.19)	.89
Total tau	−25.07 (7.69)	.001	−83.27 (46.67)	.08
p-tau₁₈₁	−8.79 (2.04)	<.001	−11.85 (11.85)	.32
Lumipulse
Aβ42	133.21 (113.5)	.25	157.52 (3186)	.96
Aβ40	−3453 (1886)	.08	−17393 (49 774)	.73
Total tau	−575.4 (253.1)	.03	1331.4 (6200)	.83
p-tau₁₈₁	−95.67 (43.42)	.04	110.53 (1096)	.92
Aβ42/Aβ40	0.05 (0.02)	.003	0.18 (0.41)	.67
Simoa
NFL	−322.5 (93.65)	<.001	−757.2 (499.9)	.13

Abbreviations: Aβ, amyloid β; CSF, cerebrospinal fluid; NFL, neurofilament light; p-tau, phosphorylated tau.

^{^a}

Adjustment for age, sex, education years, Montreal Cognitive Assessment score, APOE4, hypertension, diabetes, and creatinine.

^{^b}

Estimates are the slope of the association between biomarker level and percentage with African ancestry.