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. 2022 Sep 23;12:986236. doi: 10.3389/fonc.2022.986236

Table 2.

Cox proportional hazards regression model assessing the effect of patient-specific variables on overall survival.

Cox proportional hazards regression (Wald test, P <0.0001)
HR 95% CI P value
Age < 75
Male gender
ECOG >= 2
Squamous histology
Never smoker
BMI < 18.5 kg/m2
NLR < 3.24
Sarcopenia
PNI < 41
irAE = 0 		0.72
0.98
2.88
0.73
0.49
0.81
1.28
2.12
3.02
2.04 		0.36-1.55
0.55-1.75
1.42-5.71
0.32-1.49
0.16-1.21
0.25-2.24
0.62-2.52
1.10-3.97
1.42-6.26
1.14-3.75 		0.3791
0.9454
0.0027
0.4195
0.1539
0.7100
0.4906
0.0209
0.0034
0.0185

Cox proportional hazards regression model: (Days, Survival) ~ Age < 75 + Male gender + ECOG >= 2 + Squamous histology + Never smoker + BMI < 18.5 + NLR < 3.24 + Sarcopenia + PNI < 41 + Number of irAE = 0. HR, hazard ratio; CI, confidence interval; ECOG PS, Eastern Cooperative Group performance status; BMI, body mass index; NLR, neutrophil-to-lymphocyte ratio; PNI, prognostic nutrition index; irAE, immune-related adverse event. Variables significantly associated with overall survival are highlighted in bold.