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. 2022 Sep 23;12:1007918. doi: 10.3389/fonc.2022.1007918

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Copyright © 2022 Cui, Liu, Wang, Gu, Wang, Sun and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clustering analysis via consensus. (A) When K = 3, the clustering was the most stable. (B) Survival analysis of the three clusters. The prognosis of Cluster 1 is the poorest. (C) A heat map depicting the differences in CRL expression and clinical features between the three clusters. (D, E) The immune checkpoints genes PD-L1 and CTLA-4, as well as prognosis-related CRLs, have a co-expression relationship. Stromal score (F), Immune score (G), ESTIMATE score (H), the abundance of T cells CD4 memory activated (I), T cells regulatory (J), T cells gamma delta (K) and NK cell resting (L) in three clusters were shown.