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. 2022 Sep 23;12:1007918. doi: 10.3389/fonc.2022.1007918

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Copyright © 2022 Cui, Liu, Wang, Gu, Wang, Sun and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic model construction and evaluation. (A) In the training cohort, the patient with different risk score, survival status, and CRLs expression were shown. (B) Survival analysis of training cohort and the prognosis of high-risk group was significantly worse. (C) ROC curve revealed that in the training cohort, the AUC values for 1, 3, and 5-years OS were 0.700, 0.691, and 0.807, respectively. (D, G) In the testing and entire cohort, the patient’s risk score, survival status, and CRLs expression were shown. (E)The high-risk group’s prognosis in the testing cohort was also significantly worse. (F) In the testing cohort, AUC values of 1, 3, and 5-year OS were 0.606, 0.651, and 0.683, respectively, according to the ROC curve. (H) In the entire cohort, survival analysis revealed worse outcomes in the high-risk group. (I) In the entire cohort, the AUC values of the model in 1, 3, and 5-years OS were 0.649, 0.674 and 0.748, respectively.