Figure 7.

Expression analysis of m⁶A-related genes and human leukocyte antigen (HLA) related genes, mutation analysis. (A) Differential expression of m⁶A-related genes HNRNPC, RBM15, YTHDC1, YTHDF3, YTHDF2, YTHDC2, METTL14, WTAP, HNRNPA2B1, FMR1 were observed between the high-risk group and the low-risk groups. (B) The human leukocyte antigen gene analysis. HLA-DQA1, HLA-DRB6, HLA-DQB1, HLA-DRB1, HLA-DPB1, HLA-L, HLA-DOA, HLA-DPA1, HLA-J, HLA-DQB2, HLA-DMA, HLA-E, HLA-DQA2, and HLA-G were observed to be differentially expressed between high-risk and low-risk groups. (C) The mutation landscape of the high-risk group and draw the results into a waterfall diagram. (D)The waterfall diagram shows the mutation of patients in the low-risk group, and the mutation rate of APC was also highest. (E) Tumor mutation burden (TMB) analysis between the two risk groups. (F) Pearson-correlation analysis showed that there was a significant negative correlation between TMB and risk score. (G–K) Expression analysis of mismatch repair (MMR) protein. The expressions of MLH1, MSH2, MSH6 and EPCAM were significantly up-regulated in the low-risk group, while the expression of PMS2 showed no statistical difference between the two risk groups. ns, not significant,*P < 0.05, **P < 0.01, ***P < 0.001.