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. 2022 Sep 23;13:952775. doi: 10.3389/fphar.2022.952775

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Copyright © 2022 Zhang, Zhang, Gao, Wang, Gao, Li, Sun, Wen and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of TP on miR-146a and the TLR7/NF-κB signaling pathway. (A) The effect of TP on miR-146a expression in the spleen of MRL/lpr mice. (B) The effects of TP on miR-146a expression in Raji cells at different time points. (C) The effect of TP on TLR7 mRNA expression in Raji cells at different time points. (D) The effect of TP on the protein expression of the TLR7/NF-κB signaling pathway in Raji cells. (E) Inhibitory efficiency of a miR-146a inhibitor on miR-146a in Raji cells at different concentrations and treatment durations. (F) The effect of TP on TLR7 mRNA expression in Raji cells upon treatment with a miR-146a inhibitor. (G) The effect of TP on the expression of TLR7 signaling pathway proteins in Raji cells treated with a miR-146a inhibitor. (*p < 0.05, **p < 0.01, ***p < 0.001).