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. 2022 Sep 23;13:938891. doi: 10.3389/fendo.2022.938891

Table 2.

The results of observational mediation analysis.

Estimation 95% CI lower 95% CI upper p-value
TC
ACME
ADE
Total effect
Prop.Mediated
HDL

−0.00031
0.058
0.058
−0.0046

−0.0010
0.050
0.049
−0.017

0.00
0.070
0.070
0.00

0.13
p<2 × 10−16
2 × 10−16
0.13
ACME 0.0059 0.0029 0.010 <2 × 10−16
ADE 0.052 0.045 0.060 <2 × 10−16
Total effect 0.058 0.051 0.060 <2 × 10−16
Prop.Mediated 0.102 0.049 0.15 <2 × 10−16
LDL
ACME
ADE
Total effect
Prop.Mediated
0.00013
0.058
0.058
0.0020
−0.00020
0.051
0.051
−0.0034
0.000
0.060
0.070
0.010
0.44
<2 × 10−16
<2 × 10−16
0.44
TG
ACME
ADE
Total effect
Prop.Mediated

0.0052
0.053
0.058
0.089

0.0035
0.046
0.051
0.058

0.010
0.060
0.060
0.12

<2 × 10−16
<2 × 10−16
<2 × 10−16
<2 × 10−16

ACME, average causal mediation effect; ADE, average direct effect.