Table 3.
The sensitivity of observational mediation analysis.
| Estimation | 95% CI lower | 95% CI upper | p-value | |
|---|---|---|---|---|
| TC ACME ADE Total effect Prop.Mediated HDL |
0.0002 0.058 0.058 0.0024 |
−0.00009 0.052 0.052 −0.0015 |
0.00 0.06 0.06 0.01 |
0.22 <2 × 10−16 <2 × 10−16 0.22 |
| ACME | 0.0065 | 0.0041 | 0.010 | <2 × 10−16 |
| ADE | 0.052 | 0.046 | 0.060 | <2 × 10−16 |
| Total effect | 0.059 | 0.054 | 0.060 | <2 × 10−16 |
| Prop.Mediated | 0.107 | 0.068 | 0.14 | <2 × 10−16 |
| LDL | ||||
| ACME ADE Total effect Prop.Mediated |
0.00036 0.058 0.058 0.0066 |
−0.00025 0.052 0.052 −0.0043 |
0.000 0.060 0.060 0.020 |
0.26 <2 × 10−16 <2 × 10−16 0.26 |
| TG ACME ADE Total effect Prop.Mediated |
0.0030 0.055 0.058 0.051 |
0.0015 0.050 0.052 0.025 |
0.00 0.060 0.060 0.080 |
<2 × 10−16 <2 × 10−16 <2 × 10−16 <2 × 10−16 |
ACME, average causal mediation effect; ADE, average direct effect.