Table 6.
The results of reverse MR.
| Methods | nSNPs | Betas (95% CI) | p-value | |
|---|---|---|---|---|
| Urate–BMI | IVW | 25 | −0.022 (−0.054, 0.0092) | 0.16 |
| MR-Egger | 25 | |||
| Slope | −0.031 (−0.085, 0.022) | 0.26 | ||
| Intercept | 0.00097 | 0.68 | ||
| Urate–TC | IVW | 33 | 0.031 (−0.038, 0.10) | 0.38 |
| MR-Egger | 33 | |||
| Slope | 0.070 (−0.040, 0.18) | 0.22 | ||
| Intercept | −0.0045 | 0.38 | ||
| Urate–TG | IVW | 28 | 0.071 (−0.039, 0.18) | 0.21 |
| MR-Egger | 28 | |||
| Slope | −0.0069 (−0.18, 0.16) | 0.94 | ||
| Intercept | 0.0010 | 0.26 | ||
| Urate–HDL | IVW | 28 | −0.026 (−0.062, 0.010) | 0.16 |
| MR-Egger | 28 | |||
| Slope | 0.014 (−0.041, 0.068) | 0.63 | ||
| Intercept | −0.0051 | 0.074 | ||
| Urate–LDL | IVW | 28 | −0.0040 (−0.047, 0.039) | 0.86 |
| MR-Egger | 28 | |||
| Slope | 0.030 (−0.037, 0.097) | 0.38 | ||
| Intercept | −0.0044 | 0.20 |
The Bonferroni method was used to correct the significance level of the causal association between exposures and serum urate, with p<0.0056 (0.05/9) being statistically significant.