Table 3.
Distribution of breast cancer synchronous brain metastases all-cause mortality and hazard risk associated with various prognostic factors.
| Variables | Categories | Deaths N (%) | Univariable | Multivariable | ||
|---|---|---|---|---|---|---|
| HR (95%) | p-Value | HR (95%) | p-Value | |||
| Age | Continuous | 1,042 (100) | 1.018 (1.013, 1.024) | <0.001 | 1.019 (1.013, 1.024) | <0.001 |
| Year | 2011 | 208 (19.96) | Ref. | Ref. | ||
| 2012 | 178 (17.08) | 0.957 (0.782, 1.170) | 0.665 | |||
| 2013 | 210 (20.15) | 0.948 (0.780, 1.153) | 0.594 | |||
| 2014 | 199 (19.1) | 1.077 (0.882, 1.314) | 0.468 | |||
| 2015 | 170 (16.31) | 0.997 (0.809, 1.229) | 0.978 | |||
| 2016 | 77 (7.39) | 0.895 (0.683, 1.173) | 0.422 | |||
| Race | NHW | 637 (61.13) | Ref. | Ref. | ||
| NHB | 213 (20.44) | 1.301 (1.113, 1.519) | 0.001 | 1.266 (1.071, 1.496) | 0.006 | |
| NHAI/AN | 5 (0.48) | 0.603 (0.250, 1.453) | 0.259 | 0.783 (0.322, 1.905) | 0.590 | |
| NHAPI | 70 (6.72) | 0.968 (0.756, 1.239) | 0.793 | 1.180 (0.912, 1.527) | 0.208 | |
| Hispanic | 117 (11.23) | 0.859 (0.705, 1.046) | 0.131 | 0.909 (0.739, 1.118) | 0.366 | |
| Region | Northeast | 194 (18.62) | Ref. | Ref. | ||
| Midwest | 97 (9.31) | 1.214 (0.951, 1.549) | 0.119 | 1.008 (0.776, 1.310) | 0.951 | |
| South | 293 (28.12) | 0.956 (0.797, 1.146) | 0.628 | 0.915 (0.733, 1.143) | 0.434 | |
| West | 458 (43.95) | 0.840 (0.710, 0.993) | 0.042 | 0.927 (0.774, 1.110) | 0.407 | |
| Marital status | Married | 405 (38.87) | Ref. | Ref. | ||
| Others | 637 (61.13) | 1.350 (1.192, 1.530) | <0.001 | 1.211 (1.062, 1.380) | 0.004 | |
| Insurance status | Insured | 722 (69.29) | Ref. | Ref. | ||
| Others | 320 (30.71) | 1.026 (0.899, 1.170) | 0.704 | |||
| Primary tumor site | Central | 45 (4.32) | Ref. | Ref. | ||
| Upper-inner | 57 (5.47) | 1.593 (1.078, 2.356) | 0.020 | 1.591 (1.071, 2.363) | 0.022 | |
| Lower-inner | 26 (2.5) | 0.892 (0.550, 1.446) | 0.641 | 1.026 (0.629, 1.675) | 0.917 | |
| Upper-outer | 188 (18.04) | 1.113 (0.804, 1.541) | 0.520 | 1.340 (0.963, 1.865) | 0.082 | |
| Lower-outer | 41 (3.93) | 1.255 (0.822, 1.917) | 0.292 | 1.461 (0.952, 2.242) | 0.083 | |
| Axillary tail | 14 (1.34) | 1.495 (0.820, 2.725) | 0.189 | 1.766 (0.957, 3.262) | 0.069 | |
| Others | 671 (64.4) | 1.324 (0.979, 1.791) | 0.068 | 1.430 (1.052, 1.944) | 0.022 | |
| T-Stage | 1 | 131 (12.57) | Ref. | Ref. | ||
| 2 | 203 (19.48) | 0.968 (0.777, 1.207) | 0.774 | |||
| 3 | 126 (12.09) | 1.057 (0.828, 1.350) | 0.655 | |||
| 4 | 340 (32.63) | 1.190 (0.973, 1.456) | 0.091 | |||
| Others | 242 (23.22) | 1.137 (0.919, 1.407) | 0.236 | |||
| LNPRate | 0–20% | 21 (2.02) | Ref. | Ref. | ||
| 21–40% | 11 (1.06) | 0.775 (0.373, 1.607) | 0.493 | 0.875 (0.419, 1.827) | 0.722 | |
| 41–60% | 5 (0.48) | 0.694 (0.261, 1.841) | 0.463 | 0.782 (0.293, 2.086) | 0.624 | |
| 61–80% | 10 (0.96) | 1.087 (0.512, 2.309) | 0.829 | 1.267 (0.594, 2.704) | 0.541 | |
| 81–100% | 83 (7.97) | 1.177 (0.729,1.899) | 0.506 | 1.208 (0.744,1.964) | 0.445 | |
| Unexamined | 758 (72.74) | 1.599 (1.036, 2.468) | 0.034 | 1.505 (0.967, 2.343) | 0.070 | |
| Others | 154 (14.78) | 1.384 (0.877, 2.185) | 0.163 | 1.423 (0.894, 2.262) | 0.137 | |
| Subtype | HR+/HER2– | 369 (35.41) | Ref. | Ref. | ||
| HR+/HER2+ | 129 (12.38) | 0.766 (0.626, 0.936) | 0.009 | 0.770 (0.627, 0.945) | 0.012 | |
| HR–/HER2+ | 112 (10.75) | 1.090 (0.882, 1.346) | 0.427 | 1.076 (0.865, 1.338) | 0.513 | |
| Triple-negative | 215 (20.63) | 2.020 (1.702, 2.398) | <0.001 | 2.111 (1.763, 2.529) | <0.001 | |
| Unknown | 217 (20.83) | 1.986 (1.678, 2.351) | <0.001 | 1.882 (1.579, 2.242) | <0.001 | |
| Bone metastases | No | 388 (37.24) | Ref. | Ref. | ||
| Yes | 654 (62.76) | 0.878 (0.775, 0.996) | 0.043 | 0.899 (0.784, 1.030) | 0.123 | |
| Liver metastases | No | 672 (64.49) | Ref. | Ref. | ||
| Yes | 370 (35.51) | 1.372 (1.208, 1.559) | <0.001 | 1.543 (1.344, 1.770) | <0.001 | |
| Lung metastases | No | 538 (51.63) | Ref. | Ref. | ||
| Yes | 504 (48.37) | 1.217 (1.077, 1.374) | 0.002 | 1.119 (0.985, 1.273) | 0.085 | |
| Income* | Continuous | 1,042 (100) | 0.570 (0.405, 0.800) | 0.001 | 0.497 (0.324, 0.763) | 0.001 |
| Education* | Continuous | 1,042 (100) | 1.000 (0.990, 1.011) | 0.971 | - | - |
Income*, median household income, increased by per $10 000 annual; Education*, high school education percent, increased by per 10%; NHW, Non-Hispanic White; NHB, Non-Hispanic Black; NHAI/AN, Non-Hispanic American Indian/Alaska Native; NHAPI, Non-Hispanic Asian or Pacific Islander.