Table 4.
Distribution of breast cancer synchronous brain metastases cancer-specific mortality and hazard risk associated with various prognostic factors.
| Variables | Categories | Deaths N (%) | Univariable | Multivariable | ||
|---|---|---|---|---|---|---|
| HR (95%) | p-Value | HR (95%) | p-Value | |||
| Age | 807 (100%) | 1.013 (1.007, 1.019) | <0.001 | 1.016 (1.010, 1.023) | <0.001 | |
| Year | 2011 | 167 (20.69%) | Ref. | Ref. | ||
| 2012 | 132 (16.36%) | 0.886 (0.704, 1.11) | 0.300 | - | - | |
| 2013 | 172 (21.31%) | 0.972 (0.782, 1.207) | 0.797 | - | - | |
| 2014 | 148 (18.34%) | 0.996 (0.794, 1.249) | 0.970 | - | - | |
| 2015 | 127 (15.74%) | 0.923 (0.727, 1.171) | 0.507 | - | - | |
| 2016 | 61 (7.56%) | 0.889 (0.656 1.204) | 0.447 | - | - | |
| Race | NHW | 493 (61.09%) | Ref. | Ref. | ||
| NHB | 165 (20.45%) | 1.302 (1.091, 1.553) | 0.003 | 1.153 (0.959, 1.387) | 0.131 | |
| NHAI/AN | 5 (0.62%) | 0.790 (0.327, 1.906) | 0.599 | 1.094 (0.449, 2.665) | 0.843 | |
| NHAPI | 55 (6.82%) | 0.983 (0.743, 1.299) | 0.901 | 1.071 (0.803, 1.427) | 0.642 | |
| Hispanic | 89 (11.03%) | 0.846 (0.675, 1.06) | 0.147 | 0.843 (0.669, 1.063) | 0.149 | |
| Region | Northeast | 148 (18.34%) | Ref. | Ref. | ||
| Midwest | 75 (9.29%) | 1.231 (0.932, 1.625) | 0.143 | - | - | |
| South | 233 (28.87%) | 1.000 (0.814, 1.229) | 0.999 | - | - | |
| West | 351 (43.49%) | 0.847 (0.699, 1.026) | 0.090 | - | - | |
| Marital status | Married | 304 (37.67%) | Ref. | Ref. | ||
| Others | 503 (62.33%) | 1.418 (1.229, 1.635) | 0.001 | 1.266 (1.090, 1.472) | 0.002 | |
| Insurance status | Insured | 536 (66.42%) | Ref. | Ref. | ||
| Others | 271 (33.58%) | 1.175 (1.015, 1.36) | 0.030 | 1.165 (0.994, 1.365) | 0.060 | |
| Primary tumor site | Central | 36 (4.46%) | Ref. | Ref. | ||
| Upper-inner | 43 (5.33%) | 1.493 (0.958, 2.325) | 0.076 | - | - | |
| Lower-inner | 16 (1.98%) | 0.679 (0.376, 1.224) | 0.197 | - | - | |
| Upper-outer | 149 (18.46%) | 1.0994 (0.764, 1.582) | 0.610 | - | - | |
| Lower-outer | 31 (3.84%) | 1.181 (0.731, 1.910) | 0.497 | - | - | |
| Axillary tail | 6 (0.74%) | 0.783 (0.330, 1.859) | 0.579 | - | - | |
| Others | 526 (65.18%) | 1.289 (0.919, 1.806) | 0.142 | - | - | |
| T-Stage | 1 | 82 (10.16%) | Ref. | Ref. | ||
| 2 | 156 (19.33%) | 1.191 (0.911, 1.556) | 0.202 | 1.234 (0.942, 1.618) | 0.127 | |
| 3 | 102 (12.64%) | 1.378 (1.030, 1.843) | 0.031 | 1.340 (0.998, 1.801) | 0.052 | |
| 4 | 287 (35.56%) | 1.615 (1.263, 2.064) | <0.001 | 1.536 (1.197, 1.972) | 0.001 | |
| Others | 180 (22.3%) | 1.353 (1.042, 1.757) | 0.023 | 1.331 (1.022, 1.733) | 0.034 | |
| LNPRate | 0–20% | 19 (2.35%) | Ref. | Ref. | ||
| 21–40% | 10 (1.24%) | 0.779 (0.362, 1.676) | 0.522 | - | - | |
| 41–60% | 5 (0.62%) | 0.771 (0.288, 2.066) | 0.605 | - | - | |
| 61–80% | 8 (0.99%) | 0.965 (0.422, 2.206) | 0.933 | - | - | |
| 81–100% | 64 (7.93%) | 0.999 (0.598, 1.667) | 0.995 | - | - | |
| Unexamined | 577 (71.5%) | 1.334 (0.844, 2.109) | 0.217 | - | - | |
| Others | 124 (15.37%) | 1.230 (0.758, 1.993) | 0.404 | - | - | |
| Subtype | HR+/HER2– | 289 (35.81%) | Ref. | Ref. | ||
| HR+/HER2+ | 110 (13.63%) | 0.836 (0.670, 1.041) | 0.109 | 0.865 (0.693, 1.081) | 0.202 | |
| HR–/HER2+ | 90 (11.15%) | 1.118 (0.883, 1.417) | 0.355 | 1.072 (0.842, 1.364) | 0.573 | |
| Triple-negative | 169 (20.94%) | 2.014 (1.659, 2.444) | <0.001 | 2.185 (1.792, 2.665) | <0.001 | |
| Unknown | 149 (18.46%) | 1.715 (1.406, 2.092) | <0.001 | 1.777 (1.448, 2.181) | <0.001 | |
| Bone metastases | No | 286 (35.44%) | Ref. | Ref. | ||
| Yes | 521 (64.56%) | 0.952 (0.824, 1.100) | 0.507 | - | - | |
| Liver metastases | No | 506 (62.7%) | Ref. | Ref. | ||
| Yes | 301 (37.3%) | 1.480 (1.282, 1.707) | <0.001 | 1.616 (1.389, 1.880) | <0.001 | |
| Lung metastases | No | 405 (50.19%) | Ref. | Ref. | ||
| Yes | 402 (49.81%) | 1.288 (1.122, 1.479) | <0.001 | 1.169 (1.012, 1.350) | 0.033 | |
| Income* | Continuous | 807 (100%) | 0.403 (0.273, 0.596) | <0.001 | 0.408 (0.271, 0.615) | <0.001 |
| Education* | Continuous | 807 (100%) | 1.006 (0.994, 1.018) | 0.317 | - | - |
Income*, median household income, increased by per $10 000 annual; Education*, high school education percent, increased by per 10%; NHW, Non-Hispanic White; NHB, Non-Hispanic Black; NHAI/AN, Non-Hispanic American Indian/Alaska Native; NHAPI, Non-Hispanic Asian or Pacific Islander.