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Adduct species generated by methylglyoxal (MG). (a) Shows the hydration equilibrium reaction of MG (red), which lies to the right in aqueous solution. MG can form stable adducts with both guanine and lysine. (b) Shows abbreviated mechanisms for MG modification of deoxyguanosine to form three adducts. Only cMG‐dG is reversible, as indicated.
