FIGURE 5.

Intron–exon structure of GSTX proteins. An alignment of GSTX proteins is shown, with exon–exon junctions shown in bold and highlighted in yellow (including the amino acid immediately upstream and downstream of the junction). Of the sand fly GSTX genes, one representative protein of the 4‐exon gene structure and one of the 3‐exon structures is shown for each species. AgGSTX1 = AGAP003257 (originally annotated as GST unclassified 2, GSTU2); AgGSTX2 = AGAP009342 (originally annotated as GST unclassified 3, GSTU3); AaGSTX1 = AAEL000092; AaGSTX2 = AAEL010500. In the protein identifiers: AGAP = Anopheles gambiae PEST strain; AAEL = Aedes aegypti Liverpool strain; PPAI = Phlebotomus papatasi Israel strain; LLOJ = Lutzomyia longipalpis Jacobina strain; ‘‐PA’, ‘‐PB’ and so forth indicate protein isoforms of the same gene; ‘_a’, ‘_b’ and so forth (for the sand fly proteins only) indicate separate genes created by manual editing of a gene model