FIGURE 1.

Structural schematic of identified ENaC CAPs. CAP1 (Prss8, prostasin), ⁴ , ⁵ CAP2 (Tmprss4), ⁶ CAP3 (St14/Matriptase), ⁶ Tmprss3, ⁷ Tmprss2, ⁸ , ⁹ uPA (urokinase‐type plasminogen activator), ¹⁰ , ¹¹ plasminogen, ¹² , ¹³ , ¹⁴ , ¹⁵ trypsin, ¹⁶ chymotrypsin, ¹⁴ tissue ¹⁷ , ¹⁸ and plasma kallikrein, ¹⁹ elastase, ²⁰ furin, ²¹ factor VII activating protease, ²² cathepsin B, ²³ , ²⁴ cathepsin S, ¹⁴ meprin β ²⁵ and serralysin. ²⁶ Predicted structural domains of mouse proteases are indicated ²⁷ : CUB, complement C1r/C2s, urchin embryonic growth factor, bone morphogenic protein 1; EGF, epidermal growth factor‐like; apple; kringle; GPI, glycophosphatidylinositol anchor; LDL‐A, low density lipoprotein A; MAM, meprin, A5 protein, receptor protein phosphatase μ; MATH, meprin and TRAF‐C homology; P/Homo B, paired basic amino acid residue‐cleaving enzyme/homo sapiens B; PAN, PAN/apple; SEA, sperm protein, enterokinase and agrin; SRCR, scavenger receptor cysteine‐rich; TM, transmembrane