FIGURE 3.

Identified consensus sites for proteolytic ENaC cleavage by CAPs in mouse. Illustration of the mouse α‐, β‐ and γ‐ENaC subunits depicting in vitro identified mouse CAP cleavage sites. α‐ENaC amino acid residues numbered in blue and γ‐ENaC in green. Furin cleaves at two sites in the α subunit and at one site in the γ subunit. ²¹ CAP1, ⁷⁵ CAP2, ⁷⁶ tissue kallikrein, ¹⁷ plasma kallikrein ¹⁹ and plasmin ¹⁵ cleave mouse γ‐ENaC distal to the furin cleavage site