Key Points • Vaccination coverage is generally much lower than the minimum 75% target proposed by WHO among patients with systemic autoimmune diseases. • To improve the vaccination coverage, an active campaign was implemented in the years 2019/2020 and 2020/2021 within the Rheumatology Department of the Niguarda Hospital (Milan, Italy). • Compared with 2018/2019, a trend for increase in vaccination coverage was reported in 2019/2020 season (+ 10.7%, p = 0.055; 45.5% of coverage) and a significant increase was reported in 2020/2021 (+ 31.2%, p < 0.001; 65.9% of coverage) season. • Obtained results support the implementation of active vaccination campaigns to increase vaccination coverage among patients with systemic autoimmune diseases.