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. 2022 Sep 23;13:911806. doi: 10.3389/fimmu.2022.911806

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Copyright © 2022 Hu, Feng, Li, Yu, Rashid, Xing, Ruan, Lu, Wei and Shao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sequence and structural analyses of R5 and X4 Envs from subject 1808. (A) Full-length Env amino acid alignment of pseudoviruses In1808-3 (X4) and In1808-4 (R5). Variable regions V1–V5 are shown in boxes. (B) The structural alignment of V2 loop, V3 loop, and V4 loop; the whole structure is shown in cartoon, the main difference amino acids are highlighted by spheres model, and In1808-3 in warm pink, In1808-4 in green. (C) Structural analysis for the V3 region features points in binding of co-receptors CXCR4 using the V3-docking model. The whole structure is shown in cartoon, and the key residues are shown in sticks.