TABLE 8.

Top 20 genes by p value increased in DSA‐positive mABMR (E, F, L, N = 248) versus No rejection

Gene symbol	Gene name	Transcript set annotation	p value	FDR	No rejection	DSA‐positive mABMR
KLRD1	Killer cell lectin‐like receptor subfamily D, member 1	NK; ABMR‐RAT	2 × 10−227	1 × 10−222	41	96
GNLY	Granulysin	NK; ABMR‐RAT	8 × 10−223	1 × 10−218	53	208
PLA1A	Phospholipase A1 member A	IFNG‐inducible (GRIT)	4 × 10−216	3 × 10−212	231	623
PRF1	Perforin 1 (pore forming protein)	NK; ABMR‐RAT	2 × 10−208	1 × 10−204	87	180
CCL4	Chemokine (C‐C motif) ligand 4	NK; ABMR‐RAT	8 × 10−183	4 × 10−179	73	331
WARS	Tryptophanyl‐tRNA synthetase	IFNG‐inducible (GRIT)	7 × 10−180	3 × 10−176	557	1108
FGFBP2	Fibroblast growth factor binding protein 2	NK; ABMR‐RAT	3 × 10−169	1 × 10−165	40	102
GBP4	Guanylate binding protein 4	IFNG‐inducible (GRIT)	4 × 10−167	1 × 10−163	225	570
S1PR5	Sphingosine‐1‐phosphate receptor 5	NK; ABMR‐RAT	7 × 10−166	2 × 10−162	19	30
NKG7	Natural killer cell group 7 sequence	NK; ABMR‐RAT	2 × 10−165	5 × 10−162	164	293
TRDV3	T cell receptor delta variable 3	NK; ABMR‐RAT	2 × 10−164	4 × 10−161	13	31
CXCL11	Chemokine (C‐X‐C motif) ligand 11	IFNG‐inducible (GRIT)	2 × 10−163	4 × 10−160	20	165
TRDC	T cell receptor delta constant	NK; ABMR‐RAT	3 × 10−161	6 × 10−158	52	131
LYPD5	LY6	ABMR‐RAT	2 × 10−158	4 × 10−155	16	30
CD160	CD160 molecule	NK; ABMR‐RAT	1 × 10−153	2 × 10−150	25	63
CCL4L1	Chemokine (C‐C motif) ligand 4‐like 1	NK; ABMR‐RAT	5 × 10−153	8 × 10−150	28	92
KLRF1	Killer cell lectin‐like receptor subfamily F, member 1	ABMR‐RAT, NKB	6 × 10−153	9 × 10−150	22	41
IDO1	Indoleamine 2,3‐dioxygenase 1	IFNG‐inducible (GRIT)	2 × 10−151	3 × 10−148	103	452
SH2D1B	SH2 domain containing 1B	NK; ABMR‐RAT, NKB	3 × 10−144	4 × 10−141	12	24
GBP1	Guanylate binding protein 1, interferon‐inducible	IFNG‐inducible (GRIT)	1 × 10−143	2 × 10−140	305	870

Note: Gray shading signifies NK cell‐expressed genes.

Abbreviation: FDR, false discovery rate.