TABLE 9.
Top 20 genes by p value increased in DSA‐negative mABMR (E, F, L, N = 150) versus No rejection
| Gene symbol | Gene name | Transcript set annotation | p value | FDR | No rejection | DSA‐negative mABMR |
|---|---|---|---|---|---|---|
| GNLY | Granulysin | ABMR‐RAT | 4.17 × 10−144 | 2.07 × 10−139 | 53 | 182 |
| KLRD1 | Killer cell lectin‐like receptor subfamily D, member 1 | ABMR‐RAT | 2.18 × 10−133 | 3.60 × 10−129 | 33 | 75 |
| PRF1 | Perforin 1 (pore forming protein) | ABMR‐RAT | 8.66 × 10−128 | 8.57 × 10−124 | 87 | 165 |
| PLA1A | Phospholipase A1 member A | IFNG‐inducible (GRIT) | 4.87 × 10−125 | 3.44 × 10−121 | 231 | 549 |
| FGFBP2 | Fibroblast growth factor binding protein 2 | ABMR‐RAT | 3.78 × 10−107 | 1.87 × 10−103 | 40 | 93 |
| WARS | Tryptophanyl‐tRNA synthetase | IFNG‐inducible (GRIT) | 1.80 × 10−103 | 8.11 × 10−100 | 640 | 1196 |
| CCL4 | Chemokine (C‐C motif) ligand 4 | ABMR‐RAT | 2.77 × 10−102 | 1.05 × 10−98 | 73 | 276 |
| NKG7 | Natural killer cell group 7 sequence | ABMR‐RAT | 1.61 × 10−101 | 5.70 × 10−98 | 164 | 275 |
| KLRC3 | Killer cell lectin‐like receptor subfamily C, member 3 | ABMR‐RAT | 1.67 × 10−99 | 5.51 × 10−96 | 7 | 14 |
| TRDV3 | T cell receptor delta variable 3 | ABMR‐RAT | 1.91 × 10−98 | 5.91 × 10−95 | 13 | 27 |
| CXCL11 | Chemokine (C‐X‐C motif) ligand 11 | IFNG‐inducible (GRIT) | 6.10 × 10−98 | 1.78 × 10−94 | 20 | 142 |
| S1PR5 | Sphingosine‐1‐phosphate receptor 5 | ABMR‐RAT | 2.38 × 10−96 | 6.21 × 10−93 | 19 | 27 |
| CD160 | CD160 molecule | ABMR‐RAT | 7.45 × 10−95 | 1.76 × 10−91 | 25 | 56 |
| GBP4 | Guanylate binding protein 4 | IFNG‐inducible (GRIT) | 9.55 × 10−92 | 1.97 × 10−88 | 225 | 507 |
| KLRF1 | Killer cell lectin‐like receptor subfamily F, member 1 | ABMR‐RAT, NKB | 1.46 × 10−91 | 2.90 × 10−88 | 22 | 38 |
| GZMB | Granzyme B (granzyme 2, cytotoxic T‐lymphocyte‐associated serine esterase 1) | ABMR‐RAT | 4.12 × 10−89 | 7.29 × 10−86 | 56 | 149 |
| TRDC | T cell receptor delta constant | ABMR‐RAT | 4.58 × 10−89 | 7.82 × 10−86 | 39 | 120 |
| IDO1 | Indoleamine 2,3‐dioxygenase 1 | IFNG‐inducible (GRIT) | 4.97 × 10−89 | 8.20 × 10−86 | 103 | 400 |
| KLRC1 | Killer cell lectin‐like receptor subfamily C, member 1 | ABMR‐RAT | 3.27 × 10−85 | 4.76 × 10−82 | 15 | 41 |
| GBP1 | Guanylate binding protein 1, interferon‐inducible | IFNG‐inducible (GRIT) | 3.19 × 10−81 | 4.16 × 10−78 | 305 | 780 |
Note: Gray shading signifies NK cell‐expressed genes.
Abbreviation: FDR, false discovery rate.