FIGURE 3.

Significantly altered genes. (a) Significantly mutated genes were identified using MutSigCV, OncodriveCLUST, and OncodriveFML. Genes reported significant (q < 0.1) by two or more tools are displayed. (b) Genes with significant copy‐number aberrations reported in previous studies are summarized. CNAs are displayed as squares, and mutations and small indels, as higher rectangles. Recurrently amplified genes included MDM2, CCND1, CDK4, SKP2, KIT, NOTCH2, GAB2, YAP1, MYC, and PAK1. Regions of significant copy loss included CDKN2A, NF1, PTEN, CBL, and others involved in DNA repair and chromatin remodeling