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. 2022 Sep 23;13:1012552. doi: 10.3389/fphar.2022.1012552

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Copyright © 2022 Wu, Yang, Yu and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HER2 mediates multiple signaling pathways in breast cancer. HER2 dimerizes with other members of the EGFR family, activates downstream signaling pathways, and then regulates cell growth, proliferation, differentiation, apoptosis, and metastasis. PI3K: phosphoinositide 3-kinase; PTEN: phosphatase and tensin homolog deleted on chromosome ten; PIP2: phosphati-dylinositol-4,5-bisphosphate; PIP3: phosphatidylinositol-3,4,5-trisphosphate; PDK1: 3-phosphoinositide-dependent protein kinase 1; AKT: protein kinase B; mTOR: mammalian target of rapamycin; MAPK: mitogen-activated protein kinase; JAK: janus-activated kinase; STAT: signal transducer and activator of transcription.