FIGURE 5.

(a) Schematic illustration of self‐assembled hybrid NGs for enhanced enzyme‐regulated US and tumor chemotherapy. DOX release profile from LCNGs under varied pH values (b) and substrates by the irradiation of ultrasound (c) at 37 °C. (d) In vivo tumor US images and their corresponding mean gray values of the mice before and after intra‐tumorous injection of LCNGs under different time points (pre, 0, 10, 20, and 30 min). Circles in redlines indicate the injection sites in the tumors. Scale bar is 0.5 cm. (e) In vivo US images and their corresponding mean gray values of the tumor‐bearing mice before and after intravenous injection of LCNGs at different time points (10, 30, 60 min). Reprinted with permission from Wu et al. (2021). Copyright 2021. American Chemical Society