Table 2.
Pharmacokinetic parameters of pseudoephedrine after oral administration with GTE or water in healthy volunteers
| Pseudoephedrine | Water phase (control) | GTE phase | ||
|---|---|---|---|---|
| Geometric mean | Geo CV (%) | Geometric mean | Geo CV (%) | |
| C max (ng/mL) | 474.8 | 34.6 | 407.3 | 27.4 |
| GMR (90% CI) | 0.858 | (0.757–0.958) | ||
| T max (h) | 4.0 | (1.5–6.0) | 3.5 | (1.5–8.0) |
| AUC0–24 (h ng/mL) | 5396.5 | 37.7 | 5309.6 | 36.6 |
| GMR (90% CI) | 0.984 | (0.931–1.037) | ||
| AUC0–∞ (h ng/mL) | 5965.8 | 43.1 | 6107.8 | 42.4 |
| GMR (90% CI) | 1.024 | (0.906–1.142) | ||
| t 1/2 (h) | 6.5 | 31.1 | 7.7 | 31.6 |
| GMR (90% CI) | 1.174 | (0.908–1.439) | ||
| A e (mg) | 68.7 | 21.0 | 63.2 | 20.4 |
| GMR (90% CI) | 0.920 | (0.846–0.994) | ||
| CLR (mL/min) | 212.1 | 53.3 | 198.3 | 50.2 |
| GMR (90% CI) | 0.935 | (0.813–1.058) | ||
Pseudoephedrine (120 mg) was orally administered with water (150 mL), or an aqueous solution of EGCG‐concentrated green tea extract (150 mL) in 10 healthy Japanese volunteers. The T max values are expressed as median (range).
A e, amount excreted unchanged into urine over 24 hours; AUC, area under the plasma concentration‐time curve; CI, confidence interval; CL R, renal clearance; C max, peak plasma concentration; CV, coefficient of variation; GMR, geometric mean ratio; GTE, green tea extract; T max, time to C max; t 1/2, terminal half‐life.