TABLE 5.

Cox regression models describing the associations between the individual biomarkers and all‐cause mortality

Inflammatory biomarker	HR true value	HR standardized value a	p‐value	HR true value	HR standardized value b	p‐value
MIF	1.019	1.123	.021	1.010	1.062	.292
Periostin	1.002	1.192	.002	1.001	1.150	.028
IGFBP1	1.003	1.279	<.001	1.002	1.170	.011
IGFBP3	0.858	0.877	.031	0.884	0.900	.159
IGF−1	1.000	0.927	.304	1.000	1.051	.566
Cathepisin S	1.009	1.054	.423	1.005	1.032	.672
Resistin	1.007	1.087	.149	0.997	0.968	.680
Osteopontin	1.005	1.076	.236	0.997	0.952	.518
AXL6	1.030	1.087	.162	1.028	1.080	.266
GAS6	1.013	1.037	.429	0.996	0.989	.882
GDF−15	1.214	1.297	<.001	1.153	1.210	.006
Granulysin	1.095	1.175	.003	1.090	1.165	.026
PTX3	1.061	1.166	<.001	1.053	1.145	.049
EPCR	1.009	1.105	.006	1.009	1.096	.218
sTNFR1	1.402	1.264	<.001	0.977	0.984	.845
Syndecan	1.028	1.120	.014	0.982	0.929	.448
CXCL16	4.214	1.443	<.001	2.786	1.299	<.001
YKL40	1.003	1.242	<.001	1.001	1.103	.120
Chemerin	1.002	1.136	.034	1.001	1.052	.481
NGAL	1.001	1.093	.131	1.000	1.033	.688
TCC	1.477	1.143	.014	1.245	1.078	.389

Cox regression model adjusted for: age, BMI, sex, dialysis vintage, eGFR, deceased donor, type of CNI, smoking status, pretransplant DM or PTDM, and immunological risk ^c .

^a Each biomarker was tested alone the model as both its true and standardized value (adjusted for the variables described above).

^b All biomarkers were included together in the model as both its true and standardized value (adjusted for the variables described above).

^c Immunological high risk was defined as one of either: PRA >20%, ABO‐incompatible transplantation, or more than two prior kidney transplants.