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. 2022 Jun 28;112(3):615–626. doi: 10.1002/cpt.2672

Figure 4.

Figure 4

Parameter sensitivity analysis for baseline plasma concentration of coproporphyrin I (CPI) and AUCR for CPI–rifampin interaction. (a) Normalized sensitivity coefficient of CPI model parameters for baseline CPI or CPI AUCR (AUC with rifampin/AUC without rifampin) calculated based on the developed CPI model for a typical healthy participant. (b) Percent change in baseline CPI or CPI AUCR in severe CKD relative to healthy population calculated based on the magnitude of CKD‐related physiological changes estimated in the CPI CKD model. Volume of liver represents volume of the whole liver including both V LV and V LT . AUC, area under the plasma concentration‐time curve; CKD, chronic kidney disease; CL active,CPI , hepatic uptake clearance; CL B,CPI , biliary clearance; CL R,CPI , renal clearance; f u,p,CPI , fraction unbound in plasma; f u,L,CPI , fraction unbound in liver; k syn , endogenous synthesis rate; Q H , hepatic blood flow; Rb, blood to plasma ratio; V C,CPI , volume of central compartment; V LT , volume of liver tissue; V LV , volume of liver vascular.