Figure 6.
Developmental hypoxia significantly increases H2O2 production in rat heart mitochondria from male fetuses. Each panel represents a different respiratory state. n = 8 (NC from 6 litters), 11 (NM from 6 litters), 12 (HC from 7 litters), 8 (HM from 6 litters). *p< .05. Significance was assessed using a linear mixed model (nested). Error bars show mean ± SEM. CI, complex I; CII, complex II; ETC, electron transport capacity; HC, hypoxia control; HM, hypoxia melatonin; NC, normoxia control; NM, normoxia melatonin; OXPHOS, oxidative phosphorylation; ROX, residual oxygen consumption; SUIT, substrate–uncoupler–inhibitor–titration.