Figure 7.
Developmental hypoxia does not change H2O2 production in rat heart mitochondria from female fetuses. Each panel represents a different respiratory state. n = 8 (NC from 7 litters), 4 (NM from 3 litters), 11 (HC from 8 litters), 9 (HM from 7 litters). Significance was assessed using a linear mixed model (nested). Error bars show mean ± SEM. CI, complex I; CII, complex II; ETC, electron transport capacity; HC, hypoxia control; HM, hypoxia melatonin; NC, normoxia control; NM, normoxia melatonin; OXPHOS, oxidative phosphorylation; ROX, residual oxygen consumption; SUIT, substrate–uncoupler–inhibitor–titration.