Figure 1.

Diagram of the ZIKV genome. Regions coding for each structural and nonstructural protein are demarcated. The genome is translated as a large polyprotein, which is then cleaved by viral NS2B‐NS3 protease complex and host cell proteases to give three structural proteins and seven nonstructural proteins. Arrows in red indicate sites of cleavage by viral NS2B‐NS3 protease; arrows in blue indicate sites of cleavage by host cell proteases; the arrow in green indicates the site of cleavage by host cell furin, resulting in a mature glycoprotein M. [Color figure can be viewed at wileyonlinelibrary.com]