TABLE 1.

Fast‐acting, non‐selective, non‐competitive NMDA receptor antagonists

	Phencyclidine (PCP)	Ketamine (Ketalar)	Esketamine (Spravato)
Primary use	Illegal street drug	Anesthetic	Treatment‐resistant depression
Other uses	Anesthetic (withdrawn)	Psychiatric disorders	Acute suicidality
		Illegal street drug
Route of administration	Snorted/inhaled	IV/IM/snorted/inhaled	Nasal spray device
Abuse & dependence a	High potential	Moderate‐low potential	Moderate‐low potential

Abbreviations: IV, intravenous; IM, intramuscular.

^a US Drug Enforcement Administration Controlled Substance Schedule II and III.