. 2022 Jun 26;42(7):567–579. doi: 10.1002/phar.2707

TABLE 5.

Esketamine trials in patients with active suicidal ideation with intent

Study	Patient Population	Treatment Groups	Difference in Suicidality (CGI‐SS‐r) @ 24 h ^a	Baseline MADRS score (0–60)	Change from baseline @ 24 h	LS Mean fr placebo (SE)	p Value v Placebo
Canuso et al. Am J Psychiatry 2018 (PERSEVERE) ³¹	N = 68, age 18–64 Acutely suicidal ^b	Esk 84 mg twice weekly + AD	NS	38.5	−19.2	‐7.2 (2.85)	p = < 0.05
Canuso et al. Am J Psychiatry 2018 (PERSEVERE) ³¹	N = 68, age 18–64 Acutely suicidal ^b	Placebo twice weekly + Ad ^c	—	38.8	−12.0	—	—
Fu et al. J Clin Psychiatry 2020 (ASPIRE‐1) ³³	N = 226, age 18–64 Acutely suicidal	Esk 84 mg twice weekly + AD	NS	41.3	−16.4	−3.8 (1.39)	p < 0.05
Fu et al. J Clin Psychiatry 2020 (ASPIRE‐1) ³³	N = 226, age 18–64 Acutely suicidal	Placebo twice weekly + AD	—	41.0	−12.8	—	—
Ionescu et al. Neuropsychopharmacol 2021 (ASPIRE‐2) ³²	N = 230, age 18–64 Acutely suicidal	Esk 84 mg twice weekly + AD	NS	39.5	−15.7	−3.9 (1.39)	p < 0.05
Ionescu et al. Neuropsychopharmacol 2021 (ASPIRE‐2) ³²	N = 230, age 18–64 Acutely suicidal	Placebo twice weekly + AD	—	39.9	−12.4	—	—

Abbreviations: AD, anti‐depressant; CGI‐SS‐r, Clinical Global Impression‐Severity of Suicidalty‐revised; LS Mean, least squares mean; MADRS, Montgomery Asberg Depression Rating Scale; NS, Not statistically significant; SE, standard error.

^{^a}

Difference from placebo by Analysis of Covariance.

^{^b}

Acutely suicidal is suicidal ideation with intent assessed in emergency department or hospital inpatient unit.

^{^c}

Standard‐of‐care treatment (initial psychiatric hospitalization and newly initiated or optimized oral antidepressant therapy).