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. 2022 Aug 10;600(17):4001–4017. doi: 10.1113/JP282753

Figure 7. LTP of SLM interneurons alters excitation–inhibition balance in the temporoammonic pathway.

Figure 7

A, experimental set‐up for recording disynaptic IPSCs from CA1 pyramidal cells elicited by electrical stimulation of the SLM (stim) or optogenetic stimulation of EC afferents (light). SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum. B, effect of NBQX (10 μM) on IPSCs elicited by alternate electrical and optogenetic stimulation. Reduction of IPSCs by NBQX quantified on right (stim: P = 0.834; light: P = 0.050). C, representative experiment and traces showing LTP of feedforward inhibition induced by optogenetic TBS of EC afferents (EC‐TBS). D, pooled dataset showing EC‐TBS‐induced LTP of disynaptic IPSCs (black; P = 0.002), but not of monosynaptic EPSCs (white; P = 0.982), with representative traces (IPSCs same as in panel D) (group comparison: P = 0.001). [Colour figure can be viewed at wileyonlinelibrary.com]