Table 3.

Genes associated with polymicrogyria

Type of PMG	Gene	Mode of inheritance	Reference
Bilateral frontoparietal PMG	ADGRG1, GPR56	AR	[27,56]
Bilateral perisylvian PMG	PIK3R2	De novo	[57]
	SRPX2	Maternal	[58]
Bilateral temporooccipital PMG	FIG4	AR	[59]
Bilateral asymmetric PMG	TUBB2B	AD	[13]
Bilateral asymmetric PMG and lissencephaly	TUBA1A, TUBB2B	De novo	[61,62,63]
Bilateral PMG	MECP2	De novo	[63]
Unilateral PMG	PAX6	Maternal	[64]
PMG and lissencephaly	TUBA1A	AD	[65]
PMG and agenesis of corpus callosum, microcephaly	EOMES	AD	[30]
PMG and microcephaly	WDR62, RTTN	AR	[66,67]
PMG and optic nerve hypoplasia	TUBA8	AR	[68]
PMG and band-like calcification	OCLN	AR	[14]
PMG and Warburg Micro syndrome	RAB18	AR	[69]
PMG and Goldberg-Shprintzen syndrome	KIAA1279	AR	[70]
PMG and CK syndrome	NSDHL	X-linked	[71]
PMG and Knobloch syndrome	COL18A1	AR	[72]
Warburg Micro syndrome (characterized by ocular and neurodevelopmental abnormalities, including PMG)	RAB3GAP	AR	[73]

PMG: Polymicrogyria; AD: Autosomal dominant; AR: autosomal recessive