FIGURE 1.

Image processing overview. Image processing included a community standard preprocessing pipeline (e.g., FSL's eddy) followed by a three‐dimensional atlas‐based region of interest (ROI) HTH definition (magenta outline, bottom left). HTH MD was summarized by the median value. Inset images are composed of relative high (top) and low (bottom) sample median HTH MD images. DWI, diffusion‐weighted imaging; FSL, FMRIB Software Library; HTH, hypothalamic; MD, mean diffusivity; ROI, region of interest [Color figure can be viewed at wileyonlinelibrary.com]